GAEBoston

Interactive comparison

Knee arthritis treatments, side by side

Toggle treatments on or off and highlight one to compare how it stacks up.
Illustration of a clinician and patient reviewing treatment option cards together at a desk
Comparison of knee osteoarthritis treatments
Compare
How it worksStrengthens muscles, reduces joint loadSteroid calms inflammation; HA adds lubricationHeat disables pain-carrying nervesBlocks abnormal vessels feeding synovial inflammationReplaces joint surfaces with implants
InvasivenessNone
Needle in joint
Needles near nerves
Pinhole catheter access
Major surgery
AnesthesiaNoneLocalLocal ± light sedationLocal + twilight sedationGeneral or spinal
RecoveryNone
1–2 days
Few days
Most resume normal activity in days
6 weeks to 3+ months
Typical duration of reliefOngoing with adherence
Weeks to a few months
About 6–12 months; nerves may regrow
Studies report relief lasting 1–2+ years in many patients
Often 15–20+ years
Treats underlying inflammation?IndirectlyTemporarily (steroid)No — blocks pain signalYes — targets synovitis blood supplyRemoves diseased joint
Best suited forAll stages, first lineFlares, early-to-moderate OAModerate–severe OA, non-surgical patientsMild–moderate OA after failed conservative careSevere, bone-on-bone OA
Key risksMinimal
Cartilage effects with repeated steroids, glucose spikes
Numbness, temporary soreness
Temporary skin discoloration, access-site bruising
Infection, clots, stiffness, revision surgery
Preserves native knee?YesYesYesYes — does not preclude future surgeryNo

Bars show a simplified favorability rating (more = more favorable) for general education. Durations are typical ranges from published literature; individual results vary.

Wondering if GAE could help your knee?

Take the 2-minute WOMAC-based candidacy assessment.

Start assessment